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Cancer's Sinister Dance with the Immune System: How Hijacking the STING Pathway Fuels Disease Progression

Cancer’s Sinister Dance with the Immune System: How Hijacking the STING Pathway Fuels Disease Progression

Researchers at Memorial Sloan Kettering Cancer Center and Weill Cornell Medicine have discovered how cancer cells manipulate the immune system to advance disease progression. The culprits are chromosomal instability and the STING pathway. While the STING pathway is usually a protective mechanism of the immune system, long term activation can assist the spread of cancer. Cancer cells "hijack" the STING pathway, turning it into a promoter of disease progression, calling into question the use of STING pathway-targeting drugs for advanced cancer treatment. Additionally, the researchers developed 'ContactTracing', a tool that predicts cell-to-cell interactions and offers insights into cellular responses within tumors. The tool indicates that prolonged STING pathway activation attracts immune-suppressing cells, aiding cancer. These findings reveal intricate interactions between cancer cells and the immune system, offering new insights for potential therapeutic strategies.

Full article here: https://ipllfirm.com/all-insights/news-and-articles/cancers-sinister-dance-with-the-immune-system-how-hijacking-the-sting-pathway-fuels-disease-progression/